Archive for April, 2010

http://www.endfatigue.com/web-newsletters/nl_55c_04-21-2010.html

Two new studies suggest that osteoporosis medications (biphosphonates) can cause abnormal bone formation. This suggests that after five years of use, no further benefit is seen and that medication should be stopped for a while, or perhaps even long term. The good news? Natural alternatives are far more effective than the medications and can be used long term. They can even be taken with, or instead of, the medications.

A spot of sunbathing may be just the thing to lift a man’s libido, say experts after an Austrian study finds testosterone is boosted by vitamin D.

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Discussions of the HCG protocol and diet.

I became a client/patient of Corinne Furnari in 2004 after three different doctors had been unable to explain why I was becoming increasingly tired, although I looked like I was in perfect health. By the time I finally walked into Corinne’s office, I felt I had become a walking zombie. She very quickly diagnosed the underlying imbalance, set about correcting it and in the process taught me how to achieve the proper nutritional, exercise and supplement regimen for me, as an individual. She thinks outside the box, is tuned into a wide variety of integrative medicine techniques, does not believe in a one-size-fits-all approach to diagnosis or prescriptions, and is adamant that the key to good health is knowledge about one’s body. I learned more from her about my body, health and nutrition than I had in the prior 30 years from all my health care providers combined. I cannot thank her enough for bringing me back to health and for teaching me so much. In addition to reading, writing and arithmetic, schools should teach what Corinne knows about health. I continue to recommend her to both women and men.

Giselle Minoli, New York City

I’m a 39 year old with old (approximately 20 years) injuries to my knees include strains to MCL in both knees, complete ACL tear in right knee with allograft repair, 80% tear in right ACL with surgical tightening, and early stage osteoarthritis with degenerative cartilage pitting in both knees diagnosed through an MRI.

After constant pain and swelling surfaced around the 10 year mark, the prognosis from my Orthopedic was: eventual knee replacement(s) after the joints deteriorate to an extreme point. Suggested protocol was to take prescription-strength ibuprofen for pain and swelling, weight reduction, and to wait until a knee replacement was needed. (more…)

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Beat SUGAR ADDICTION NOW!  Interview with Dr Jacob Teitelbaum creator of this Cutting Edge Program to diagnose and treat your type of sugar addiction which can put you on the road to feeling great!

Link: vitality101.com

Sun, Mar 28 2010
By JoAnne Allen

WASHINGTON (Reuters) – Bingeing on high-calorie foods may be as addictive as
cocaine or nicotine, and could cause compulsive eating and obesity,
according to a study published on Sunday.

The findings in a study of animals cannot be directly applied to human
obesity, but may help in understanding the condition and in developing
therapies to treat it, researchers wrote in the journal “Nature
Neuroscience.”

The study, involving rats, found that overconsumption of high-calorie food
can trigger addiction-like responses in the brain and that high-calorie food
can turn rats into compulsive eaters in a laboratory setting, the article
said.

The scientists also found decreased levels of a specific dopamine receptor
— a brain chemical that allows a feeling of reward — in overweight rats,
as has been reported in humans addicted to drugs, the article said. “Obesity
may be a form of compulsive eating. Other treatments in development for
other forms of compulsion, for example drug addiction, may be very useful
for the treatment of obesity,” researcher Paul Kenny of The Scripps Research
Institute in Florida said in a telephone interview.

Obesity-related diseases cost the United States an estimated $150 billion
each year, according to U.S. federal agencies. An estimated two-thirds of
American adults and one-third of children are obese or overweight.

For the study, Kenny and colleagues headed to the grocery store.

“We basically bought all of the stuff that people really like — Ding-Dongs,
cheesecake, bacon, sausage, the stuff that you enjoy, but you really
shouldn’t eat too often,” he said.

They also bought healthy foods and devised a diet plan for three groups of
rats.

One group ate a balanced healthy diet. Another group received healthy food,
but had access to high-calorie food for one hour a day. Rats in the third
group were fed healthy meals and given unlimited access to high-calorie
foods.

The rats in the third group developed a preference for the high-calorie
food, munched on it all day and quickly became obese, Kenny said.

The rats in the experiment had also been trained to expect a minor shock
when exposed to a light. But when the rats that had unlimited access to
high-calorie food were shown the light, they did not respond to the
potential danger, Kenny said. Instead, they continued to eat their snacks.

“What we’re seeing in our animals is very similar to what you’d see in
humans who overindulge,” he said. “It seemed that it was okay, from what we
could tell, to enjoy snack foods, but if you repeatedly overindulge, that’s
where the problem comes in.”

Kapoor D. Eur J Endocrinol 2006; 254(6): 899-906. Testosterone replacement
therapy improves insulin resistance, glycaemic control, visceral adiposity
and hypercholesterolaemia in hypogonadal men with type 2 diabetes.

JAMA 2006;295:1288-1299. EL Ding. Harvard. Boston USA. Cross- sectional
studies indicated that testosterone level was significantly lower in men
with type 2 diabetes ….Similarly, prospective studies showed that men with
higher testosterone levels (range, 449.6-605.2 ng/dL) had a 42% lower risk
of type 2 diabetes

16 Aug 2005

A detectable decline in energy production by mitochondria — the organelles
that are the cell’s furnace for energy production — seems to be a key
problem leading to insulin resistance, and thus to type 2 diabetes,
according to studies by Howard Hughes Medical Institute researchers.

The research team said that insulin resistance — an impaired response to
the presence of insulin — is detectable as early as 20 years before the
symptoms of diabetes become evident. In fact, insulin resistance is now seen
as the best predictor that type 2 diabetes will eventually develop, said the
study’s senior author, Gerald I. Shulman, a Howard Hughes Medical Institute
investigator at the Yale University School of Medicine.

In the new study examining how insulin interacts with the energy-producing
mitochondria inside living cells, Shulman and his colleagues found that the
rate of insulin-stimulated energy production by mitochondria is
significantly reduced in the muscles of lean, healthy young adults who have
already developed insulin resistance and who are at increased risk of
developing diabetes later in life.

“This is further evidence that people who are prone to develop diabetes have
signs of mitochondrial dysfunction,” Shulman said in an interview. This is
important because mitochondria are the “energy factories” inside cells and
produce most of the chemical power needed to sustain life.

The new research, which is published in the September 2005 issue of the
open-access journal PLoS Medicine, indicates that a decreased ability to
burn sugars and fats efficiently is an early and central part of the
diabetes problem. Their new data also suggest the basic defect lies within
the mitochondria, which exist in almost every cell.

The young adults studied by the research team are the offspring of parents
who have type 2 diabetes, adding support to the idea that the risk can be
inherited, and that the problem begins well before diabetes symptoms become
evident. In an earlier research study published in the journal Science,
Shulman and his colleagues had also found that healthy, lean older
individuals have a major reduction in mitochondrial energy production that
leads to accumulation of fat inside muscle cells resulting in insulin
resistance. “These data may explain the increased prevalence of type 2
diabetes that occurs with aging” Shulman said.

In the new studies, Shulman and his Yale colleagues — Kitt Falk Petersen
and Sylvie Dufour — discovered that the mitochondria in muscle cells
respond poorly to insulin stimulation. Normal mitochondria react to insulin
by boosting production of an energy-carrying molecule, ATP, by 90 percent.
But the mitochondria from the insulin-resistant people they tested only
boosted ATP production by 5 percent.

“These data demonstrate that insulin-stimulated rates of ATP synthesis are
reduced in the insulin-resistant offspring of parents with Type 2 diabetes,”
the researchers wrote in their report. Their work offers new insight into
the early steps in the development of insulin resistance, and offers
important clues to where the problem lies.

Among their findings was also evidence for a severe reduction in the amount
of insulin stimulated phosphorus transport into the muscle cells of the
insulin-resistant participants. This also points to a dramatic defect in
insulin signaling and may explain the observed abnormalities in
insulin-stimulated power production in the insulin-resistant study subjects,
since phosphorus is a key element in the mitochondrion’s complex
energy-production process, the oxidative-phosphorylation pathway.

“Type 2 diabetes affects about 171 million people worldwide, and the number
of people likely to be affected by diabetes is expected to double by 2030,”
Shulman and his colleagues added. “Type 2 Diabetes develops when resistance
to insulin action is combined with impaired insulin secretion,” resulting in
a severe oversupply of sugars and fats in the blood. “Studies have
demonstrated the presence of insulin resistance in virtually all patients
with type 2 diabetes,” Shulman added. Diabetes is the leading cause of
blindness, end stage kidney disease and non-traumatic loss of limb, and has
associated health care costs that exceed $130 billion a year in the United
States.

Such fundamental research is important because the problem of diabetes is
growing rapidly worldwide, and effective drugs are needed to halt or even
reverse the disease process. Understanding how the cell’s internal energy
system is controlled by the hormone, insulin, and how the mitochondria
behave, may eventually lead to improved ways to overcome or prevent
diabetes.

Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
http://www.hhmi.org

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Andropause, Looking at disease prevention and reversal Dr. Comite is an nationally recognized endocrinologist and advocate of prospective, preventive, integrative and patient-centric medicine. “It’s preposterous to say andropause doesn’t exist and that men’s bodies don’t change…

Dr Comite’s Website